Nextfuse: Running Nextflow® in Domino
Nextfuse bridges Nextflow®'s pipeline execution model with Domino's enterprise compute platform — giving bioinformaticians the scale, traceability, and control their work demands.
Managed compute for your Nextflow® pipelines.
Domino gives life sciences teams browser access, abundant storage, customized compute environments, and Git repository integration. Nextflow® gives them the pipeline orchestration language their workflows for processing high-memory, high-compute, long-running tasks in parallel. Nextfuse makes them work together — executing each Nextflow® process as its own Domino job, without modification, with precisely the CPU and memory it needs.
Because Domino runs on cloud-based Kubernetes, your Nextflow® workloads scale on demand. No continuously-running, costly VMs. No overprovisioning to handle peak load.
KSM helps customers through every phase of Domino implementation — from environment capacity planning and installation through custom compute environment definition, Git integration, and load and scalability testing. Whether for bioinformatics, biostatistics, or other life sciences usages, we have the accelerators and experience to get you up and running fast and with full GxP compliance.
Two accelerators. One fully-integrated solution.
Each accelerator in the Nextfuse family solves a distinct challenge in running production Nextflow® workloads inside Domino. Together they cover execution and observability.
Pipeline execution as Domino jobs
Nextfuse streamlines Nextflow® pipelines inside Domino, executing each process as a Domino job with a tailored compute environment. Perfect for bioinformaticians and biostatisticians who want Nextflow®'s orchestration with Domino's infrastructure.
- Per-process CPU and memory allocation — no more one-size-fits-all compute
- Browser-based access, abundant storage, and Git integration via Domino
- Kubernetes-backed auto-scaling eliminates the need for standing VMs, scaling up to meet surges in demands and scaling down when not needed to reduce costs
- Drop-in fit for pipelines already written in Nextflow® DSL
Real-time pipeline visibility
Nextflow® pipelines generate dozens of Domino jobs that are hard to differentiate in the standard jobs UI. Nextfuse Monitor understands Nextflow® execution graphs and visualizes the full pipeline in real-time — with Nextflow®-assigned process names, not opaque job IDs.
- Real-time DAG visualization as processes complete
- Processes displayed with their Nextflow®-assigned names for intuitive debugging
- Domino API integration surfaces CPU usage, memory, and log details per job
- Domino Datasets API access for web-based browsing of interim pipeline artifacts
A Drop-In Solution for Your Nextflow® Workloads
Nextfuse gives you all the safety, security, and reproducibility of Domino computing environments without having to rewrite your Nextflow® workflows. Check out the documentation at https://nextfuse.ksmpartners.com to learn more, and then click the button below to schedule a conversation with a KSM expert.
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